Preventive effect of kiwi berry ( <em>Actinidia arguta</em>) on loperamide-induced constipation

Constipation is a common intestinal disease. Kiwi berries can effectively prevent constipation. However, studies have yet to be done determine how kiwi For two weeks, mice in this study were continually orally gavaged with berry, loperamide, or combination of the two. This found that group's feces had more water than constipated mice. In addition, speed up gastrointestinal transit (GI), shorten time it takes pass first dark stool, and dramatically enhance body weight gain.&nbsp;In interstitial cells Cajal (ICC) colon tissues, alterations protein expression vasoactive peptide (VIP), cyclic adenosine monophosphate (cAMP), kinase A (PKA), aquaporin-3 (AQP3) found. At 3, 6, 12 h ICC mouse colon, VIP, cAMP, PKA, AQP3 levels lower those The berry decrease Firmicutes&nbsp;to Bacteroidetes&nbsp;ratio boost diversity quantity gut microbiota. By influencing microbiota VIP-cAMP-PKA-AQP3 signaling pathway,